Work

mGem: Innate immune sensing of HIV-1 transcription in myeloid cells—a tale of two transcription start sites

Year: 2026

Type: article

Abstract: Suppressive antiretroviral therapy (ART) in people with HIV (PWH) arrests progression to AIDS and onward viral transmission. However, viral transcription from integrated HIV-1 proviruses persists on treatment and is linked to markers of chronic immune activation, contributing to the accelerated development of comorbidities in PWH. Of particular interest are persistent responses in long-lived tissue-resident myeloid cells, which direct tissue-level inflammatory processes through cytokine secretion and interactions with other immune cell populations. Here, we review recent findings on viral nucleic acid sensing events in HIV-infected myeloid cells to shed light on possible mechanisms of persistent inflammation resulting from chronic HIV-1 transcription in myeloid cells in PWH.

Source: mBio

DOI: 10.1128/mbio.03340-25

Authors: Ivy K. Hughes, Suryaram Gummuluru

Institution: Boston University

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,900