Year: 2026
Type: preprint
Abstract: Myxobacteria represent an underexplored source of terpenoids with relatively few terpenoids and terpene synthases known from this phylum. Thirteen sesquiterpenes (1–13) representing ten distinct carbon skeletons were identified from eight myxobacterial terpene synthases. Twelve of these natural products (1–10, 12, and 13), including enantiomers of known brasilane-type sesquiterpenes (1–3) and the humulene analog viticumulin A (4), were previously unknown from myxobacteria. Moreover, ten (i.e., 1–4, 7–10, 12, 13) have not been previously reported from bacterial sources. These data demonstrate that myxobacteria represent a rich and largely untapped reservoir of terpenoids that should be further investigated.
Source: ChemRxiv
Institution: University of Florida
Language: English
Subfield: Applied Microbiology and Biotechnology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7223052152