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Daturolides A–K, cytotoxic sesquiterpene lactones from Datura wrightii

Year: 2026
Type: article
Abstract: resulted in the identification of 11 new sesquiterpene lactones, including two germacranolides (1 and 2), eight heliangolides (3-10), and an eudesmanolide (11), along with nine known sesquiterpene lactones (12-20) belonging to the eudesmanolide, germacranolide, and guaianolide classes. The structures of the new compounds were elucidated by analysis of 1D and 2D NMR spectroscopic data and high-resolution mass spectrometric data. Their absolute configurations were determined based on a combination of modified Mosher's method, ECD simulation, and X-ray diffraction experiments. The new compound 10 exhibited moderate cytotoxic activity against both TOP3B-KO and TOP3B-WT cell lines, with EC50 values in the low micromolar range.
Source: RSC Advances
DOI: 10.1039/d6ra08123a
Authors: Ji-Yeon Hwang, Brice A. P. Wilson, Lindsay Marron, Shar-Yin Naomi Huang, Ekaterina I. Goncharova, Dongdong Wang, Yves Pommier, Barry R. O'Keefe, Lin Du
Language: English
Field: Chemistry
Open Access status: gold
Estimated APC paid: $1,042
Funders: Center for Cancer Research, U.S. Department of Health and Human Services, University of Pennsylvania, National Institutes of Health, National Cancer Institute, Intramural Research Program
OpenAlex ID: W7223061988
FWCI:
Cites: 45
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Related to: 10