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Hippo-mediated trophoblast induction for modeling human chorion development with human pluripotent stem cells v1

Year: 2026

Type: preprint

Abstract: This protocol describes transient naïve resetting of human pluripotent stem cells, Hippo-mediated induction of the trophoblast lineages, and subsequent generation of three-dimensional human chorion models. The workflow provides an accessible in vitro platform for investigating early human placental development.

DOI: 10.17504/protocols.io.n92ldorr8g5b/v1

Authors: Miaoci Zhang, Ryan Lim, Mijo Simunovic

Institution: Columbia University

Language: English

Topic: Pluripotent Stem Cells Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: New York Stem Cell Foundation

OpenAlex ID: W7223082481

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