Work

Silica meets flavonoid: zwitterionic silica–quercetin nanocarriers embedded in electrospun fibers for wound healing

Year: 2026

Type: article

Abstract: , with complete bacterial inhibition observed in pre-annealed samples. The materials also exhibited excellent cytocompatibility, maintaining >80% viability in L929 fibroblasts. In an LPS-induced inflammatory model, [email protected]/PVA-PAA nanofibers significantly downregulated pro-inflammatory cytokines (IL-6, TNF-α, IFN-γ) while upregulating IL-10 and TGF-β, indicating a shift toward a pro-resolving microenvironment. Scratch wound-healing assays further revealed accelerated wound closure, with wound gaps reduced to ∼30% at 72 h compared to ∼60% in controls. By integrating a zwitterionic nanoengineered interface with sustained Q delivery, antioxidant activity, and immunomodulatory effects, this study yields a multifunctional nanofibrous platform that addresses biological processes relevant to wound healing. These findings establish Zw-SiNPs@Q/PVA-PAA nanofibers as a promising bioactive interface for advanced wound management and tissue repair applications.

Source: Nanoscale Advances

DOI: 10.1039/d6na00563b

Authors: Nesrin Horzum, Fatma Rabia Karaduman, Sena Nur Köksal, Aslı Eldem, Özlem Karakoç, Ayşegül Ülkü Metin

Institutions: Izmir Kâtip Çelebi University, Kırıkkale University, Dokuz Eylül University

Language: English

Topic: Electrospun Nanofibers in Biomedical Applications

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,962