Work

Association between preconception serum lipid levels and pregnancy complications in singleton live births from IVF/ICSI with fresh embryo transfers

Year: 2026

Type: article

Abstract: Purpose This study aimed to examine how preconception serum lipid profiles are associated with pregnancy complications in women who achieved singleton live births following assisted reproductive technology (ART). Methods This study included 1,036 women who had singleton births after ART. Preconception serum lipid measurements included low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), and triglycerides (TG). The pregnancy complication outcomes included cesarean section, gestational diabetes mellitus (GDM), preeclampsia, preterm delivery (PTD), small for gestational age (SGA), large for gestational age (LGA), low birthweight (LBW), macrosomia, and neonatal intensive care unit (NICU) admission. Results The incidence of cesarean section, GDM, preeclampsia, PTD, SGA, LGA, LBW, macrosomia, and NICU admission was 51.6%, 3.8%, 0.7%, 7.6%, 6.8%, 15.6%, 6.4%, 5.7%, and 1.8%, respectively. Women with dyslipidemia had higher rates of GDM (11.7% vs. 2.1%, p < 0.001), PTD (13.9% vs. 6.3%, p < 0.001), and LWB (10.6% vs. 5.5%, p = 0.012). After adjusting for possible confounders, TG (OR 1.49[1.11–1.99]) was positively associated with PTD. TC (OR 1.48[1.08–2.02]), LDL-C (OR 1.48[1.03–2.14]), and HDL-C (OR 3.03[1.19–7.73]) were positively associated with SGA. TC (OR 2.22[1.63–3.04]) and TG (OR 1.20[1.00–1.44]) were positively associated with GDM. Conclusion Preconception serum lipid levels were associated with pregnancy complications in women receiving ART.

Source: Frontiers in Nutrition

DOI: 10.3389/fnut.2026.1915181