Post-transfusion Haemoglobin Increment Following Packed Red Blood Cell Transfusion and Associated factors Among Children With Sickle Cell Anemia At Tertiary hospital in Tanzania: A Retrospective Observational Study
Year: 2026
Type: preprint
Study design: Observational Study
Abstract: Sickle cell anemia is an inherited hemoglobin disorder caused by a point mutation in the β-globin gene, resulting in the substitution of valine for glutamic acid at position 6. Blood transfusion is a cornerstone in managing selected complications of sickle cell anemia. However, evidence on post-transfusion hemoglobin increment among children with sickle cell anemia in resource-limited settings remains limited. This retrospective study was conducted from 2024 to 2026 among children with sickle cell anaemia diagnosed by Hemoglobin Electrophoresis aged < 14 years who received packed red blood cell (PRBC) transfusion at 10 mL/kg.The mean difference between pre- and post-transfusion hemoglobin concentrations was assessed using a paired t-test, while Spearman’s correlation was used to assess associations between hemoglobin increment and selected characteristics. A total of 100 children were included. Following PRBC transfusion, the mean hemoglobin increment was 2.86 ± 1.6 g/dL. Hemoglobin increment was significantly negatively correlated with pre-transfusion hemoglobin concentration (Spearman’s r = − 0.476, p < 0.0001). Age (r = − 0.206, p = 0.324) and body weight (r = − 0.153, p = 0.998) were negatively correlated with hemoglobin increment, but these associations were not statistically significant. Children with sickle cell anemia demonstrated a substantial but variable hemoglobin increment following 10 mL/kg PRBC transfusion. Post-transfusion hemoglobin monitoring may help assess transfusion response and guide subsequent transfusion decisions.
Source: Research Square
Language: English
Subfield: Genetics (clinical)
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7223092023