Work

Downsizing macrocycles in melanocortin peptide analogues: thioether and lactam cyclization strategies to modulate h MC3/4R agonism and antagonism

Year: 2026

Type: article

Abstract: Reducing macrocycle size while preserving the melanocortin pharmacophore provides a means to tune functional activity and receptor preference at h MC3R and h MC4R.

Source: RSC Medicinal Chemistry

DOI: 10.1039/d6md00726k

Authors: Rosa Bellavita, Luis E. Gimenez, Savannah Y. Williams, Ida Boccino, Gennaro M. Bailo, Roger D. Cone, Paolo Grieco, Francesco Merlino

Institutions: University of Naples Federico II, University of Michigan

Language: English

Topic: Chemical Synthesis and Analysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W7223094308

FWCI:

Cites: 54

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Related to: 10