Liquid‑liquid phase separation and post‑transcriptional regulation intersection: A new paradigm of RNA‑binding protein condensates in hepatocellular carcinoma malignant phenotypes (Review)
Year: 2026
Type: review
Abstract: liquid-liquid phase separation (llPS) enables rna-binding proteins (rBPs) to assemble into dynamic biomolecular condensates that influence post-transcriptional regulation. in hepatocellular carcinoma (Hcc), these condensates may alter rna processing and stability.They can also influence transcript localization and translational output.Through these effects, rBP condensates may contribute to tumor growth and metastatic progression.They may further support metabolic adaptation, immune evasion and resistance to therapy.The present review focuses on the intersection between llPS and post-transcriptional regulation in Hcc. in addition, the present review critically assessed current evidence for rBP condensate function and distinguish direct Hcc findings from mechanistic extrapolation.unresolved questions regarding causality and clinical translation were also discussed.This framework may help clarify how condensate biology contributes to Hcc and where therapeutic opportunities remain.Contents 1. introduction 2. Basic biological principles of llPS and rBP condensates 3. aberrant expression and altered phase separation capacity of key rBPs in liver cancer 4. regulation of Hcc cell proliferation and apoptosis escape by rBP condensates 5. Molecular mechanisms linking rBP condensates to Hcc invasion and metastasis 6. role of rBP condensates in metabolic reprogramming of liver cancer 7. rBP condensate-mediated regulation of the liver cancer immune microenvironment and therapeutic resistance 8. Targeting rBP condensates: a novel strategy for liver cancer diagnosis and treatment 9. challenges and future prospects 10. conclusion Liquid-liquid phase separation and post-transcriptional regulation intersection: A new paradigm of RNA-binding protein condensates in hepatocellular carcinoma malignant phenotypes (Review)
Source: Molecular Medicine Reports
Authors: Xiao Liu, Yunyi Huang
Language: English
Topic: RNA Research and Splicing
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W7223098783