One-Pot Synthesis of Oxazolines from Carboxylic Acids and Amino Alcohols using Phosphorus(V) Catalysis
Year: 2026
Type: preprint
Abstract: Oxazolines are important heterocycles for a range of industrial applications, and yet their synthesis from simple carboxylic acid and amino alcohol substrates requires multiple steps and stoichiometric reagents. Here, we demonstrate the one-pot direct synthesis using a bifunctional boronic acid/phosphorus(V) catalyst that is shown to catalyze both the amidation and cyclodehydration steps. Different classes of carboxylic acid coupling partners are surveyed, the mechanism for cyclodehydration investigated, and a variety of 2-substituted oxazolines prepared without the addition of stoichiometric reagents.
Source: ChemRxiv
Authors: Jacob J. Dalton, Christopher Sandford
Institution: The University of Texas at San Antonio
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W7223103659