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Rare metachronous advanced colorectal cancer coexisting with lymphoma: a case report with over 10-year survival

Year: 2026

Type: article

Abstract: Background: Multiple primary malignancies (MPMs) are increasingly encountered in clinical practice as cancer survivorship improves. The coexistence of colorectal cancer (CRC) and lymphoma is rare, and long-term survival exceeding 10 years in such patients has seldom been reported. Case presentation: We report a 63-year-old male patient who presented with sigmoid colon adenocarcinoma with synchronous multiple liver metastases (cT4N1M1, Stage IV) in 2015. Molecular testing of the primary sigmoid colon tumor specimen revealed wild-type KRAS, NRAS, BRAF, and PIK3CA.After multidisciplinary team (MDT) discussion, the patient received 4 cycles of FOLFIRI regimen chemotherapy as conversion therapy, achieving partial response (PR). He subsequently underwent special hepatic segmentectomy and laparoscopic-assisted radical sigmoidectomy, followed by additional chemotherapy. Evaluation in May 2016 showed complete response (CR) with no evidence of disease (NED). During regular follow-up in 2021, a left inguinal lymph node enlargement was detected. Biopsy confirmed peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), CD30-positive. The patient received 6 cycles of CHOP chemotherapy combined with local radiotherapy, achieving CR. In March 2026, retroperitoneal lymph node recurrence was confirmed, and continued chemotherapy was recommended. The patient has achieved an overall survival of over 10 years since the initial CRC diagnosis. Conclusion: This case suggests that, with MDT-guided individualized treatment, long-term survival may be achievable in patients with advanced CRC and liver metastases following conversion therapy and radical surgery. The subsequent development of a second primary PTCL-NOS highlights the importance of vigilant long-term surveillance in cancer survivors. This report adds to the limited literature on MPMs involving CRC and lymphoma with extended survival.

Source: Frontiers in Oncology

DOI: 10.3389/fonc.2026.1952530

Authors: Yue Ma, Ting Han, Xiaolin Lin, Xiuying Xiao

Institutions: Shanghai Jiao Tong University, Renji Hospital

Language: English

Topic: Multiple and Secondary Primary Cancers

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801