Herpes Simplex Esophagitis Superimposed on Eosinophilic Esophagitis in an Immunocompetent Patient
Year: 2026
Type: article
Study design: Case Report
Abstract: Herpes simplex esophagitis (HSE) rarely occurs in immunocompetent patients. Eosinophilic esophagitis (EoE) may predispose to herpes simplex virus superinfection through epithelial barrier disruption. We present an immunocompetent woman with previous EoE managed with dietary modifications without pharmacologic therapy who developed severe odynophagia. Endoscopy showed erosive esophagitis mimicking candidiasis and active EoE, histologically consistent with HSE without eosinophilic inflammation or fungal organisms. Empiric antifungals and corticosteroids were discontinued, and intravenous acyclovir was initiated with rapid improvement. Follow-up endoscopy confirmed complete mucosal healing. This case highlights the diagnostic complexity of HSE complicating EoE and the indispensable role of histopathologic evaluation.
Source: ACG Case Reports Journal
Institution: Hospital Madre Teresa
Language: English
Topic: Eosinophilic Esophagitis
Subfield: Gastroenterology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7223114779