Year: 2026
Type: article
Abstract: ABSTRACT Four previously undescribed Euphane triterpenes, comprising three dynamic epimerization pairs ( 1–3 ) and a tetranor derivative ( 5 ), as well as eight known analogues ( 4 and 6 – 12 ), have been separated from the tubers of Euphorbia antiquorum . Their structures were characterized by spectroscopic methods, including HR–ESIMS, NMR and ECD. All of them were evaluated for their inhibitory activity against the diabetic target α ‐glucosidase. Compound 5 exhibited the most potent activity with an IC 50 value of 13.6 µM. The binding mode of 5 to α ‐glucosidase was further investigated, which identified it as a mixed‐type inhibitor.
Source: Chemistry & Biodiversity
DOI: 10.1002/cbdv.71823
Authors: Ren‐Fen Ma, Chen‐Yu Wang, Kai‐Yue Liu, Hua Zhang
Institution: University of Jinan
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $3,880
Award: G4336681304
OpenAlex ID: W7223139980