Work

Copine proteins and derived bioactive peptides in tissue development and regeneration: from molecular mechanisms to biomaterial functionalization

Year: 2026

Type: review

Abstract: fluctuations, CPNE proteins translocate to the plasma membrane and recruit specific effector proteins, thereby integrating calcium dynamics with membrane remodeling, vesicular transport, and cell differentiation. While individual members display tissue-specific expression patterns-such as CPNE6 in hippocampal synaptic plasticity and CPNE7 in mesenchymal cell differentiation during odontogenesis-recent translational focus has centered on CPNE-derived bioactive peptides. Short synthetic sequences derived from the CPNE7 C2B-vWA junction region, specifically Cpne7-DP and CDP4, replicate key pro-regenerative functions of full - length proteins without requiring cell - surface receptor binding. When functionalized into biomaterial matrices (such as collagen gels and chitosan hydrogels via modified sequences UG27 and UG28), these peptides stimulate dentin tubule regeneration, osteogenic lineage commitment, biomineralization, and chondrocyte extracellular matrix deposition and angiogenesis. This review synthesizes current knowledge on CPNE structural biology, intracellular membrane translocation mechanisms, physiological tissue development, and oncological diagnostic markers.

Source: Frontiers in Bioengineering and Biotechnology

DOI: 10.3389/fbioe.2026.1889849

Authors: A. Tymińska, A. Kowalska, M. Rogińska, M. Pikuła

Institution: Gdańsk Medical University

Language: English

Topic: Bone and Dental Protein Studies

Subfield: Biochemistry

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801