High ambipolar mobility fluorinated MXene for ultrasensitive biosensing transistors
Year: 2026
Type: article
Abstract: Transition metal carbides and nitrides (MXenes) are emerging as transformative materials for bioelectronics. However, the advancement of MXene-based field-effect transistor (FET) biosensors is hindered by the lack of high-quality aqueous-stable materials and the low signal transduction efficiency intrinsic to their metallic nature. To address these issues, we report an ultrasensitive biosensing platform enabled by an in-situ fluorination strategy of MXene. By substituting unstable oxygen-containing terminations with chemically stable fluorine terminations in a mild reaction, we synthesized high-quality fluorinated MXene with the record-breaking ambipolar field-effect mobility (μ p = 10.42 cm 2 V −1 s −1 , μ n = 30.23 cm 2 V −1 s −1 ). The highly electronegative fluorinated interface suppresses interfacial electrical double-layer capacitance, boosting signal transduction efficiency. Consequently, the platform achieves the lowest limit of detection (LOD) of 0.26 fg ml −1 for Mycobacterium tuberculosis antigen MPT64 among MXene FETs up to date, accompanied by a high current response of 35.02% at LOD. Clinical validation across 126 serum samples demonstrated a diagnostic accuracy of 97.6% with a detection time of 38 s, exhibiting the high-performance and reliable biosensing in complex physiological environments.
Source: Science Advances
Institution: Fudan University
Language: English
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $4,500
OpenAlex ID: W7223143034