Work

Natural products shape microbial ecology and disease in the cystic fibrosis airway

Year: 2026

Type: review

Abstract: spp. When known, we describe the biosynthesis and roles of these natural products in microbial persistence, interspecies interactions, and virulence in the CF airway. When these roles are unknown, we infer potential roles based on evidence from the literature in different disease contexts. Finally, we briefly highlight natural products produced by the CF microbiota as novel sources for developing new antimicrobials and as drug targets to treat disease.

Source: Natural Product Reports

DOI: 10.1039/d6np00067c

Authors: Niladri Bhowmik, Reed M. Stubbendieck

Institution: Oklahoma State University

Language: English

Topic: Bacterial biofilms and quorum sensing

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Institutes of Health, National Institute of General Medical Sciences