Work

Anesthetic challenges in a child with Alport syndrome undergoing prone surgery with a laryngeal mask airway: a case report

Year: 2026

Type: article

Abstract: Introduction: Alport syndrome is a rare hereditary disorder caused by type IV collagen abnormalities and characterized by progressive kidney disease with variable extrarenal manifestations. Evidence guiding anesthetic management, particularly in pediatric patients, remains limited. Case presentation: We report the anesthetic management of a 12-year-old girl with a clinical diagnosis of X-linked Alport syndrome based on microscopic hematuria and obligate heterozygosity for a familial pathogenic COL4A5 variant undergoing elective lower-leg surgery in the prone position. Despite preserved renal function, perioperative management included careful drug selection and a propofol-based total intravenous anesthesia using a second-generation laryngeal mask airway without neuromuscular blockade. Stable ventilation was maintained throughout prone surgery, and recovery was uncomplicated with effective postoperative pain control. Conclusions: This case contributes to the limited literature on anesthetic management in pediatric Alport syndrome and highlights practical perioperative considerations regarding airway management, anesthetic technique, and renal-protective care.

Source: Frontiers in Pediatrics

DOI: 10.3389/fped.2026.1950654

Authors: Christine Gaik, Selena Knoth, Felix Schmitt, Ingelore Holzinger

Institutions: Philipps University of Marburg, Universitätsklinikum Gießen und Marburg, Klinikum Kassel

Language: English

Topic: Anesthesia and Sedative Agents

Subfield: Anesthesiology and Pain Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801