Work

Sialic Acids: From Biosynthesis and Molecular Recognition to Disease and Therapy

Year: 2026

Type: article

Abstract: Sialic acids (Sias) are nine-carbon acidic sugars that cap the majority of glycan chains on vertebrate cells, serving as universal regulators of molecular recognition and cell signaling (reviewed previously in (1-4)). The accompanying thematic series of reviews highlights the most recent significant developments in the ever-growing field of research on sialylation. They unveiled several unifying themes. First, it becomes clear that sialylation is highly context-dependent, producing distinct outcomes depending on its linkage, glycan structure, carrier molecule, cell type, and developmental stage.

Source: Journal of Biological Chemistry

DOI: 10.1016/j.jbc.2026.113688

Authors: Susan Bellis, Vladislav Panin

Institutions: University of Alabama at Birmingham, Texas A&M University

Language: English

Topic: Glycosylation and Glycoproteins Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $3,430

Funder: College of Agriculture and Life Sciences, Texas A and M University