Work

Gastric Spindle Cell Neoplasm With LMNA::NTRK1 Fusion: A Rare Mimic of Wild‐Type GIST

Year: 2026

Type: article

Abstract: Neurotrophic tyrosine receptor kinase-rearranged spindle cell neoplasms (NTRK-SCNs) are rare mesenchymal tumours defined by oncogenic rearrangements involving NTRK genes. NTRK fusions are exceedingly rare in the gastrointestinal tract and can closely resemble wild-type gastrointestinal stromal tumours (GISTs), posing a diagnostic challenge in the absence of molecular testing. We report a case of a 36-year-old woman with a distal gastric mass initially suspected to be a GIST. Surgical resection revealed a spindle cell tumour with low mitotic activity and perivascular hyalinisation. Immunohistochemistry demonstrated expression of CD34, S100 and pan-TRK and was negative for KIT/CD117 and DOG1. Molecular testing confirmed an LMNA::NTRK1 fusion, consistent with NTRK-SCN. This case highlights the importance of considering NTRK-SCN in KIT/DOG1-negative gastric spindle cell tumours.

Source: Case Reports in Surgery

DOI: 10.1155/cris/5492086

Authors: Yoonji Seo, Christopher Leung, Mitali Fadia, Christopher Seng Hong Lim, Sivakumar Gananadha

Institutions: Australian National University, Canberra Hospital, ACT Government

Language: English

Topic: Gastrointestinal Tumor Research and Treatment

Subfield: Gastroenterology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $790