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A Tanshinone IIA Sulfonate Derivative Targets USP21 to Induce SCD1 Degradation, Suppressing NSCLC Metabolism and Enhancing Antitumor Immunity

Year: 2026
Type: article
Abstract: This work identifies USP21 as an important immunometabolic regulator in NSCLC. Targeting USP21 with USP21-in6 supports further investigation of USP21 inhibition as a potential dual strategy to overcome metabolic disorders and immune suppression for NSCLC immunometabolic therapy.
DOI: 10.32604/or.2026.089127
Authors: Yang Liu, Lixue Chen, Peng Wang, Xiaoli Ma, Shuaikang Pan, Dafu Yang, Tianyu Zhou, Fang Yu, Jincheng Song, Zhaolin Sun, Zhaoxia Dai, Peng Chu
Language: English
Open Access status: bronze
OpenAlex ID: W7223169434
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