Human Amnion Grafting for Vaginal Agenesis in Mayer-Rokitansky-Kuster-Hauser Syndrome: A Case Report
Year: 2026
Type: article
Study design: Case Report
Abstract: Vaginal agenesis is a congenital condition of the female genital tract. Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome is a disorder characterised by agenesis of Mullerian structures, including the uterus and upper two-thirds of the vagina, with normally developed secondary sexual characteristics. The author presents a case of a 21-year-old married woman with primary amenorrhoea diagnosed with type 1 MRKH syndrome. The patient underwent the modified McIndoe vaginoplasty procedure with the use of a human amnion as a graft for creating a neovagina. The patient was discharged fifteen days postsurgery with training on the use of vaginal dilators. The patient was followed up weekly to assess vaginal patency. At the end of three months, the patient had approximately 7 cm of neovaginal length.Sexual intercourse was recommended thereafter.Modified McIndoe vaginoplasty with a human amnion graft is an effective, simple, safe procedure with high acceptability and a good enough functional vagina in women with MRKH syndrome.
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $275
OpenAlex ID: W7223169620