Renal denervation in internal medicine: a FADOI Position Paper on behalf of the Vicenza Hypertension Multidisciplinary Team. Endorsed by the Italian Society of Arterial Hypertension
Year: 2026
Type: article
Abstract: Resistant hypertension (RH) remains a clinical challenge in internal medicine, associated with increased cardiovascular morbidity and mortality. Renal denervation (RDN), a catheter-based intervention targeting renal sympathetic nerves, has re-emerged as a promising “adjunctive” therapy following the publication of the latest sham-controlled randomized trials. Current data demonstrate that RDN provides a modest but consistent reduction in blood pressure, with a favorable safety profile in selected patients with RH and uncontrolled hypertension, despite optimized pharmacological therapy or in those with medication intolerance. This paper reviews the pathophysiological rationale, updated clinical evidence, patient selection criteria, procedural aspects, and future perspectives of RDN, for which a multidisciplinary approach is required to ensure procedural safety and optimal outcomes. This position paper is not intended to be a new guideline but a practical recommendation on how to proceed with the selection of the patient candidate for RDN and his management before and after the procedure in internal medicine coordinated by a hypertension specialist.
Source: Italian Journal of Medicine
Institutions: Ospedale San Bortolo, International Renal Research Institute of Vicenza, Azienda ULSS 8 Berica, Ospedale dell' Angelo, Agostino Gemelli University Polyclinic, University of Pisa, Sapienza University of Rome, Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia, University of Brescia, University of Insubria, Aziende Socio Sanitarie Territoriale dei Sette Laghi, Ospedale Misericordia - Grosseto
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7223173125