Work

Emerging roles and mechanistic insights of ASRGL1 in tumorigenesis and cancer progression

Year: 2026

Type: review

Abstract: Asparaginase and isoaspartyl peptidase 1 (ASRGL1), also known as ALP, CRASH, hASNase3, is a protein encoded by the ASRGL1 gene located at chromosome 11q12.3 in humans. It belongs to the N-terminal nucleophilic (Ntn) hydrolase superfamily and catalyzes the hydrolysis of L-asparagine and isoaspartyl dipeptides, thereby participating in amino acid metabolism and protein homeostasis regulation. In recent years, accumulating evidence has shown that ASRGL1 is aberrantly expressed in multiple human cancers, however, its biological and prognostic implications vary substantially among tumor types and are highly tumor-context dependent. This review systematically summarizes the structure and function of ASRGL1, its expression patterns and clinical relevance, the reported functional roles and proposed mechanisms in tumorigenesis and progression, and discusses its potential as a candidate biomarker for clinical prognosis prediction.

Source: Frontiers in Cell and Developmental Biology

DOI: 10.3389/fcell.2026.1955895

Authors: Huiping Zeng, Zekang Li, Renhao Geng, Lujun Chen

Institutions: Nanjing Medical University, Soochow University, The First People's Hospital of Changzhou

Language: English

Topic: Amino Acid Enzymes and Metabolism

Subfield: Biochemistry

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801