Work

Two New 7/7/6/5‐Tetracyclic C25 Steroids From the Marine‐Derived Fungus Lodderomyces sp. Z‐1

Year: 2026

Type: article

Abstract: ABSTRACT Lodderomyces is recognized as a yeast genus with important applications in both food fermentation and medical research. In the present study, two new C25 steroids with a 7/7/6/5‐tetracyclic scaffold, named (11 R ,20 R )‐11‐hydroxy‐24‐oxocyclocitrinol ( 1 ) and (11 R )‐11‐hydroxy‐erythro‐23‐ O ‐methylneocyclocitrinol D ( 2 ), together with nine known analogues ( 3–11 ), were isolated and characterized from the marine‐derived fungus Lodderomyces sp. Z‐1, which was obtained from the starfish Culcita novaeguineae collected from the South China Sea. The structures and absolute configurations of new compounds were established through extensive spectroscopic analyses, quantum chemical calculations, and comparison of spectral data with those of related analogues reported in the literature. Additionally, the single‐crystal x‐ray crystallographic structure of the known compound 4 is reported here for the first time. In the anti‐inflammatory assay, compound 10 exhibited weak inhibitory activity against LPS‐induced NO production in RAW264.7 macrophages with an IC 50 value of 41.72 ± 1.81 µM.

Source: Chemistry & Biodiversity

DOI: 10.1002/cbdv.71867

Authors: Qi Zhang, Song‐Wei Li, Si‐Min Pan, Li‐Gong Yao, Yue‐Wei Guo, Ming‐Zhi Su

Institutions: Anhui University of Traditional Chinese Medicine, Shanghai University

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Applied Microbiology and Biotechnology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,880