Work

Unilateral Angle Closure as the Initial Presentation of Multiple Myeloma Metastasis

Year: 2026

Type: article

Abstract: Purpose: Ocular manifestations of multiple myeloma (MM) are rare but may affect all tissues of the eye. This report describes a patient with recurrent MM initially presenting with ocular hypertension due to angle closure, revealing extensive ocular, orbital, and systemic metastatic disease. Case Report: A 54-year-old female patient with previously treated MM presented with left eye pain, blurred vision, and an intraocular pressure of 38 mmHg. Examination revealed proptosis, restricted upward gaze, conjunctival injection with two salmon-patch lesions, and complete angle closure. Further findings included multiple ciliary body cysts, a massive choroidal mass, and retinal/choroidal detachments. She had pancytopenia. Magnetic resonance imaging confirmed recurrent MM with superior rectus muscle and spine infiltrations, and a large prevertebral lymph node mass. The patient responded well to antiglaucoma medications and was referred to her oncologist. Conclusion: MM can involve various ophthalmic structures. Patients with MM require regular examinations for early detection of ocular metastasis.

Source: Journal of Ophthalmic and Vision Research

DOI: 10.18502/jovr.v21.19965

Authors: Thao Huong Nguyen, Truong Dang Minh Pham, Thanh Nghiep Trang, Ngoc Phuong Vy Ly, Hong Y Huynh

Institution: Pham Ngoc Thach University of Medicine

Language: English

Topic: Multiple Myeloma Research and Treatments

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $200