Work

Design and synthesis of 3-(1 H -indol-3-yl)- N -(3,4,5-trimethoxyphenyl) acrylamide derivatives as anticancer agents

Year: 2026

Type: article

Abstract: -alkyl substituents favored selectivity toward MCF-7 cells, whereas 4-Br substitution and ethyl-alkyl extension preferentially enhanced activity against Hep-G2 cells. Mechanistic studies demonstrated that 10b primarily induced apoptotic cell death at lower concentrations and exposure times, whereas higher concentrations and prolonged treatment resulted in more necrotic cell death. Compound 10b also induced dose-dependent alterations in cell-cycle progression in MCF-7 cells, characterized by S-phase arrest.

Source: RSC Advances

DOI: 10.1039/d6ra03896d

Authors: Seyedeh Niloufar Ghafouri, Parviz Rashidi Ranjbar, Mohammad Mahdavi, Aida Iraji

Institutions: University of Tehran, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Shiraz University of Medical Sciences

Language: English

Topic: Heterocyclic Compound Synthesis and Bioactivity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,042