Year: 2026
Type: review
Abstract: Introduction: As a core drug in chemotherapy regimens for colorectal cancer, the clinical efficacy of oxaliplatin is compromised by multiple resistance mechanisms. Lipid metabolism, a crucial component of metabolic pathways, is known to affect the efficacy of various chemotherapeutic agents. However, to the best of our knowledge, the role of lipid metabolism in oxaliplatin resistance remains unreviewed. Areas covered: In this review, we analyze the relationship between lipid metabolism and oxaliplatin efficacy from the perspectives of DNA damage, ferroptosis, ROS accumulation, cellular dormancy, antitumor immunity, vascular remodeling, and autophagy. This review covers nearly all known oxaliplatin resistance factors, summarizing the regulatory role of lipid metabolism across both basic and clinical studies. Given that clinical studies remain relatively scarce compared to basic research, the impact of factors directly regulated by lipid metabolism on clinical outcomes is analyzed. Based on this, their relationship with oxaliplatin efficacy is inferred, and potential directions for future clinical research are highlighted. Expert opinion/commentary: By summarizing the relationship between lipid metabolism and oxaliplatin resistance, this review provides an important theoretical basis for improving chemotherapy efficacy in colorectal cancer and developing novel combination therapies based on metabolic interventions.
Source: Frontiers in Oncology
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,801
Award: G4166323308
OpenAlex ID: W7223175737