Epigenetic Silencing of ZNF471 Contributes to Osimertinib Resistance in Lung Adenocarcinoma: β-Hydroxybutyrate Associates with ZNF471 Re-Expression and Reduced Resistance-Associated Phenotypes
Year: 2026
Type: article
Abstract: ZNF471 is an epigenetically silenced modulator of osimertinib sensitivity in LUAD. BHB may enhance osimertinib response by reactivating ZNF471. ZNF471 is an epigenetically silenced modulator of osimertinib sensitivity in LUAD. BHB may enhance osimertinib response by reactivating ZNF471. Taken together, these findings suggest that BHB is associated with ZNF471 re-expression and reduced osimertinib resistance-associated phenotypes in LUAD cells, although whether ZNF471 is required for this effect remains to be determined.
Institution: Hunan Normal University
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W7223180985