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Fluoroalkynes: The Last Frontier of Organofluorine Chemistry?

Year: 2026

Type: preprint

Abstract: Molecules containing carbon-fluorine bonds are of global importance in pharmaceuticals, agrochemicals and polymers and are widely studied. However, little is known about fluoroalkynes where a fluorine atom is directly bonded to a carbon atom that forms part of a carbon-carbon triple bond. Pioneering studies in the 20th century established that these compounds are typically unstable, but their chemistry has remained largely unexplored to date. Here, we outline methods to prepare a diverse range of fluoroalkynes for the first time, rationalize the reasons behind their low stability, and demonstrate six different classes of reactions of fluoroalkynes and their difluorocyclobutadiene dimers.

Source: ChemRxiv

DOI: 10.26434/chemrxiv.15010873/v2

Authors: Sahra St John Campbell, Helen Allan, Matthew R. Penny, Sitanun Sae-Seung, Penpicha Janprasert, Mohammed Loukili, Tatiana Rogova, Marie-Therése Soroush-Pejrimovsky, Qingyu Gu, Mingxuan Lu, Dejan-Krešimir Bučar, Abil E. Aliev, Michael J. Porter, Tom David SHEPPARD

Institution: University College London

Language: English

Topic: Fluorine in Organic Chemistry

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: Leverhulme Trust, University of Texas at Dallas

OpenAlex ID: W7223184270

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