Year: 2026
Type: review
Abstract: Methionine 1-linked ubiquitin (Met1-Ub) is a non-degradative protein modification that is generated solely by the Linear Ub Chain Assembly Complex (LUBAC) and hydrolysed by the deubiquitinases OTULIN and CYLD. The Met1-Ub system has emerged as a critical regulator of immune receptor signalling, specially known for activating NF-κB downstream of the TNF receptor superfamily. Studies from human patients and mouse models have shown that the Met1-Ub system is also critical for the development, maintenance, and function of T cells. However, manipulation of the Met1-Ub system in T cells has yielded discrepant results, and the molecular underpinnings underlying the regulation of T cells by the Met1-Ub system remain unclear. This mini-review summarises the current consensus and highlights the unresolved questions surrounding the role of the Met1-Ub system in T cells.
DOI: 10.1111/sji.70155
Authors: John Rizk, Mads Gyrd‐Hansen
Institutions: University of Copenhagen, LEO Foundation
Language: English
Topic: NF-κB Signaling Pathways
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,480
Awards: G1357843206, G4129004604
OpenAlex ID: W7223185743