Air-Compatible Indole-Based NHC–Copper Catalysts for A3 Coupling Reaction
Year: 2026
Type: article
Abstract: A series of indole-based N-heterocyclic carbene (NHC) copper complexes has been developed as air-compatible catalysts for A3 coupling reactions. The optimized catalytic system efficiently promotes the three-component coupling of aldehydes, amines, and alkynes under aerobic conditions with catalyst loadings as low as 0.1 mol %. Systematic evaluation of ligand structure reveals that both electronic and steric features of the indole-derived NHC framework play key roles in modulating catalytic activity and stability under air. Notably, differences in time-dependent catalytic behavior are correlated with the air stability of the Cu–NHC complexes, providing insight into catalyst deactivation pathways. These results demonstrate the potential of indole-based NHC–copper complexes as efficient catalysts for A3 coupling reactions under operationally simple conditions.
Source: The Journal of Organic Chemistry
Institution: National Chung Hsing University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
OpenAlex ID: W7223186264