Work

A recyclable [DABCO][Imi] 2 deep eutectic solvent for multicomponent synthesis of 1,2-dihydropyridine-3-carbonitriles: in vitro antiproliferative and in silico molecular evaluation

Year: 2026

Type: article

Abstract: values of 17.44 ± 0.09 mM and 12.04 ± 0.12 mM, respectively. Molecular docking suggested that SIRT1 may serve as a potential molecular target for these compounds. Molecular docking and ADME prediction suggested that these compounds possess acceptable drug-like properties and may serve as suitable starting points for further structural optimization.

Source: RSC Advances

DOI: 10.1039/d6ra06973h

Authors: Truong-Thinh Huy Pham, Tuan-Anh Ngoc Tran, Dat Minh Tran, Huy-Hoang Le Nguyen, Hai Truong Nguyen

Institutions: Vietnam National University Ho Chi Minh City, Ho Chi Minh City University of Science

Language: English

Topic: Multicomponent Synthesis of Heterocycles

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,042