Work

Design, synthesis, and antifungal activity of (phenylethynyl) phenoxymethyl-1,3-dioxolane triazoles as novel CYP51 inhibitors

Year: 2026

Type: article

Abstract: and significantly suppresses fungal biofilm formation. In conclusion, as a CYP51 inhibitor featuring a novel scaffold, CZ14 holds great promise for further development as a highly potent and broad-spectrum antifungal agent.

Source: RSC Medicinal Chemistry

DOI: 10.1039/d6md00652c

Authors: Zixuan Gao, Cancan Cui, Mingshuo Chen, Wenzhan Hao, Kejian Li, Cunzheng Fan, Zirui Luo, Xin Su, Dongmei Zhao, Maosheng Cheng

Institution: Shenyang Pharmaceutical University

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Natural Science Foundation of China

OpenAlex ID: W7223187115

FWCI:

Cites: 32

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Related to: 10