Can the prognostic nutritional index predict survival in patients with gastric and esophagogastric junction adenocarcinoma?
Year: 2026
Type: article
Study design: Observational Study
Abstract: Background: This study aimed to evaluate the prognostic significance of the preoperative Prognostic Nutritional Index (PNI) for overall survival (OS) and disease-free survival (DFS) in patients with gastric and gastroesophageal junction adenocarcinoma. Methods: We retrospectively analyzed the data from 300 patients undergoing curative gastrectomy at Ankara Oncology Training and Research Hospital between January 2013 and 2021. We calculated PNI using the formula: PNI = (10 × serum albumin [g/dL]) + (0.005 × total lymphocyte count). Using receiver operating characteristic (ROC) curve analysis, we determined the optimal PNI cut-off value as 45.83 and subsequently stratified patients into two groups: those with PNI ≥ 45.83 and those with PNI < 45.83. We then evaluated overall survival (OS) and disease-free survival (DFS) using the Kaplan-Meier method. Results: Our findings showed that patients with PNI < 45.83 had significantly shorter OS and DFS compared to those with PNI ≥ 45.83 (OS: 42 months vs. 90 months; DFS: 39 months vs. 84 months; p < 0.001). The multivariate analysis demonstrated low PNI, advanced T-stage, a higher number of metastatic lymph nodes, and Bormann type 3 tumors to be independent negative prognostic factors for both OS and DFS. Conclusions: Low preoperative PNI was associated with poorer OS and DFS in patients with gastric and gastroesophageal junction adenocarcinoma. PNI may contribute to preoperative risk assessment; however, prospective validation is required before its routine clinical use.
Source: Frontiers in Oncology
Institutions: Ankara Etlik City Hospital, Sağlık Bilimleri Üniversitesi
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W7223187214