Work

Evaluating the impact of homoeopathy in managing the morbidity associated with grade III and IV lower limb lymphoedema in adults with lymphatic filariasis

Year: 2026

Type: article

Abstract: Introduction: Lymphatic filariasis is a major public health burden, particularly in endemic regions, with millions suffering from chronic lymphoedema and hydrocele. While mass drug administration aims to restrict transmission, effective morbidity management remains a significant challenge. Homoeopathy has reported potential in managing lymphoedema, yet evidence in cases of grade III and IV lymphoedema is limited. Methods: This open-label, exploratory, interventional study, conducted at the Regional Research Institute for Homoeopathy, Puri, Odisha, India, aimed to evaluate the effects of individualized homoeopathic medicines in managing grade III/IV unilateral/bilateral lower-limb lymphoedema associated with lymphatic filariasis. Outcomes included changes in limb circumference (Australasian Lymphology Association standards), limb volume (Water Displacement Method), health-related quality of life (7D5L scale), dermatological changes (Dermatology Life Quality Index), acute adenolymphangitis episodes, skin health, and serological markers over one year. A total of 104 eligible participants were enrolled, and followed-up monthly for one year. 61 participants dropped out of the study, and 43 participants successfully completed all the follow-ups. Results: Statistically significant improvements were observed in quality of life and dermatological indices (p-value < 0.0001), along with alleviation of limb volume. Decreased Og4C3 and TNF-α levels, resolution of entry lesions and ulcers, and reduction in occurrence of fungal infections were documented. Discussion: The study demonstrated the potential benefits of homoeopathy in managing advanced filarial lymphoedema by improving quality of life. Further controlled studies with larger sample are warranted. Clinical trial registration: https://ctri.nic.in/Clinicaltrials/pmaindet2.php?EncHid=MjY2NzE=&Enc=&userName=, identifier CTRI/2018/06/014591.

Source: Frontiers in Parasitology

DOI: 10.3389/fpara.2026.1939673