[A multicenter study on vibrating mesh nebulization of pulmonary surfactant for treating respiratory distress syndrome in preterm infants].
Year: 2026
Type: article
Abstract: OBJECTIVES: To evaluate the efficacy of noninvasive ventilation combined with vibrating mesh nebulization of pulmonary surfactant (PS) in preterm infants with respiratory distress syndrome (RDS) and to identify predictors of treatment failure. METHODS: Preterm infants with RDS (gestational age >28 weeks, birth weight >1 000 g) admitted to neonatal intensive care units at 12 hospitals between June 2023 and November 2024 were prospectively enrolled. All infants initially received nasal continuous positive airway pressure and were treated with PS administered via vibrating mesh nebulization. Infants were categorized into a success group or a failure group according to whether escalation to invasive mechanical ventilation via endotracheal intubation was required. Multivariable logistic regression was used to identify predictors of failure of vibrating mesh nebulized PS treatment. A prediction model was constructed, and its performance was assessed using receiver operating characteristic (ROC) curves and the area under the curve (AUC). RESULTS: at 30 minutes after treatment were <8 and <220 mmHg, respectively. CONCLUSIONS: <220 mmHg at 30 minutes after treatment are independent predictors of treatment failure.
Source: PubMed Central
Authors: Yu-Meng Wu, Xin Chen, Ru-Na Li, Si-Ying Sun, Rui Rao, Lu-Ling Yang, Xiao-Hong Jiang, Xue-Tao Xu, Hui Wang, Han-Qing Wang, Yin-Long Zhang, Mei Liu, Ya-Li Zhang, Qian Guo, Jin-Hong Li, De-Xin Li, Bo Wang, Hou-Jiang Luo, Jun Yang, Min Feng, Shi-Di Xie, Hong Xu, Qiao-Qiao Zou, Dan Sun, Lei Shi, Hong Wan, Zi-Ang Wang
Institution: First Affiliated Hospital of Bengbu Medical College
Language: Chinese
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7223207191