Work

The nonsense mutation of the smu-1(mn415) allele is in exon 6 at Q257, not in exon 5 at Q255

Year: 2026

Type: article

Abstract: smu-1 encodes the Caenorhabditis elegans orthologue of the spliceosomal protein SMU1. The smu-1(mn415) allele was originally identified as a suppressor of synthetic lethality between mec-8 and unc-52 and was mapped to a stop codon at amino acid position 255 in exon 5. Our Sanger sequencing analysis of the smu-1(mn415) allele shows that the stop codon is at amino acid position 257 in exon 6.

Source: microPublication biology

DOI: 10.17912/micropub.biology.002454

Authors: Nirmala Devi Rajendra Chauhan, Timothy Pearson, Alper Akay

Institution: University of East Anglia

Language: English

Topic: RNA Research and Splicing

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: diamond

Funders: UK Research and Innovation, National Institutes of Health, Directorate for Biological Sciences

Awards: G6818842463, G8482184214, Caenorhabditis Genetics Center