Year: 2026
Type: review
Study design: Study Protocol
Abstract: Introduction Dental agenesis refers to the developmental absence of at least one permanent tooth and falls under the category of dental anomalies related to tooth number. While this condition is commonly observed in permanent dentition, it is relatively rare in primary dentition. Previous meta-analyses, conducted over a decade ago, have investigated its frequency and highlighted significant variability particularly when assessing different populations. This systematic review aims to answer the research question: “What is the worldwide frequency of agenesis of permanent teeth?” Methods and analysis A literature search was conducted on 15 April 2026, using the following databases will be searched for relevant publications: MEDLINE (via PubMed), Embase, Latin American and Caribbean Health Sciences Literature, Scopus and Web of Science. Cross-sectional studies that present data on the frequency of permanent tooth agenesis, as assessed through imaging exams, in individuals without known congenital abnormalities or syndromes will be included. There will be no restrictions on language or publication date. After defining the search strategy, two independent authors will conduct the study selection process in two phases, adhering to predefined eligibility criteria. The risk of bias will be assessed using the JBI Critical Appraisal Checklist for Studies Reporting Prevalence Data. The results will be summarised narratively, and a meta-analysis will be performed if feasible. Ethics and dissemination This systematic review does not require ethical approval. On completion, it will be published in a peer-reviewed academic journal and presented at a conference. PROSPERO registration number CRD42024617722.
Source: BMJ Open
Language: English
Subfield: General Dentistry
Field: Dentistry
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,839
OpenAlex ID: W7223222874