Code and GWAS summary statistics for "Shared non-HLA genetic architecture of ankylosing spondylitis and its extra-articular manifestations"
Year: 2026
Type: dataset
Abstract: Analysis code and summary data accompanying the manuscript "Shared non-HLA genetic architecture of ankylosing spondylitis and its extra-articular manifestations localises to myeloid and lymphoid immune cells across human organs" (Xu Q, Li S, Xiao C, Tian D, Chen H; submitted). Contents:- code: all analysis scripts in run order (01-15; R and Python) with Windows launchers.- F_SpA_factorGWAS_*.tsv.gz: Genomic SEM common-factor GWAS of ankylosing spondylitis, anterior uveitis, inflammatory bowel disease and psoriasis (GRCh37; extended MHC chr6:24-36 Mb removed; effective N = 84,294).- AS/AU/IBD/PSO_meta_*.tsv.gz: fixed-effect inverse-variance meta-analyses combining FinnGen R13 with Million Veteran Program, UK Biobank, Regeneron, IIBDGC or Pan-UK Biobank summary statistics (GRCh37).- Supplementary Tables S1-S8, Table 2 and result tables (MAGMA, cell-type enrichment, scDRS, anterior segment atlas, SMR/coloc, DGIdb).- scDRS gene sets and per-cell scores in 141,448 Tabula Sapiens 2.0 immune cells.- README.md (column definitions) and MANIFEST.csv (file sizes and MD5 checksums). Large files are split by chromosome (and into _partNN where needed) so that each file is <= 20 MB. Please also cite the original data sources (FinnGen, MVP, UK Biobank, IIBDGC, Regeneron, Pan-UK Biobank, Tabula Sapiens, GEO GSE199013, eQTLGen, GTEx).
Institution: Guangzhou University of Chinese Medicine
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7223225078