Year: 2026
Type: article
Abstract: Mangrove ecosystems, between the terrestrial and marine domain, harbor a diverse and specialized microbial community, including Actinomycetia members, which produce a variety of functionally distinct bioactive metabolites. Molecular and genomic approaches have enabled the investigation of Actinomycetial diversity and identification of new strains and secondary metabolites. Mangrove-associated Actinomycetia from diverse areas have been reported in many studies. However, several habitats can still be poorly studied, hence their diversity and biosynthetic potential is lacking. This review systematically aims to highlight the study of the taxonomical diversity as well as bioactive potentials of Mangrove-associated Actinomycetia from sediments and endophytic niches from the study records published between 1988 and 2025. The integrated literature shows that these microorganisms generate diverse metabolites with antimicrobial, anticancer, antioxidant, quorum-quenching, and antibiofilm effects. Because of differences in the specific environmental conditions in mangrove ecosystems (salinity variation, tidal activities and nutrient gradients), the microbial population behaviour, adaptation and production of secondary metabolites are expected to be altered due to the particular environmental scenarios of mangrove ecosystem. Mangrove-associated Actinomycetia represent a valuable yet underexplored resource for natural product discovery. Combining established isolation methods with genetic sequencing, metabolomics and other omics based methods would be fundamental for harnessing full biosynthetic potential, allowing the discovery of new and original bioactive compounds even more quickly.
Source: Discover Oceans
Language: English
Subfield: Applied Microbiology and Biotechnology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W7223227919