Replication Data for: Allopurinol to reduce cardiovascular morbidity and mortality: A systematic review and meta-analysis
Year: 2026
Type: dataset
Abstract: This repository contains the data, documentation, and supporting materials underlying the systematic review and meta-analysis “Allopurinol to reduce cardiovascular morbidity and mortality: A systematic review and meta-analysis”, published in PLOS ONE in 2021 (https://doi.org/10.1371/journal.pone.0260844). The repository documents the systematic review workflow, including the review protocol, literature search, study selection, extraction of study characteristics, and quantitative meta-analysis. The materials are organized into folders corresponding to these stages. The repository includes documentation of the review methods and search strategy, records and materials relating to study selection, extracted study characteristics, and outcome-specific datasets used for the meta-analyses. The quantitative analysis files cover cardiovascular mortality, myocardial infarction, stroke, and a combined cardiovascular endpoint. Supporting materials include forest plots presenting pooled effect estimates, funnel plots used to assess potential publication bias, and documentation of the assessment of the quality of evidence from randomized controlled trials. The review investigated the effects of allopurinol on cardiovascular morbidity and mortality in patients with hyperuricemia. The deposited materials are derived from previously published studies included in the systematic review and provide a record of the data and analytical outputs underlying the published findings. The repository is intended to promote transparency and reproducibility and to facilitate verification and further investigation of the published results. Details of the eligibility criteria, literature search, data extraction, outcome definitions, and statistical methods are provided in the original publication and the accompanying methodological documentation.
DOI: 10.17026/ls/whszmk
Authors: K.H. van der Pol, G.A. Rongen
Institution: Radboud University Medical Center
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7223245208