Work

Innovative design and development of novel thiazole–paracetamol hybrids as COX inhibitors and immunomodulatory activity: design, synthesis, SAR, in vitro biological evaluation, and molecular docking analysis

Year: 2026

Type: article

Abstract: = 1.40 ± 0.10 and 1.74 ± 0.20 µM, respectively). The docking process of the most promising derivative 8 demonstrated strong binding affinity and various types of interactions, including hydrogen bonding, π-π stacking, and hydrophobic interactions (π-alkyl and alkyl). In addition, ADMET prediction indicated a favorable pharmacokinetic profile and acceptable toxicity levels. These findings identify compound 8 as a promising lead candidate for the development of next-generation anti-inflammatory agents with dual cyclooxygenase inhibitory and immunomodulatory properties.

Source: RSC Advances

DOI: 10.1039/d6ra07351d

Authors: Mohamed A. Salem, Radwa Ayman, Yousry A. Ammar, Moustafa S. Abusaif, Mohamed H. Helal, Ahmed Ragab