Fatal encephalitis caused by Shamonda virus Europe 1 (SHAV-EU1) in a patient with a severely weakened immune system, France, 2026
Year: 2026
Type: article
Study design: Case Report
Abstract: New Shamonda virus clades (SHAV-EU1 and SHAV-EU2) emerged in Europe in summer 2026, primarily affecting cattle. We report the first human infection with SHAV-EU1: a French patient with a severely weakened immune system developed fatal encephalitis in September 2026, 1 month after their allogeneic stem cell transplantation. Metatranscriptomics detected SHAV-EU1 in cerebrospinal fluid, confirmed by RT-PCR. Biopsies from central nervous system showed high viral loads. Investigations revealed SHAV-EU1 in serum, respiratory and stool samples at least for 2 months before encephalitis onset.
Source: Eurosurveillance
Authors: Margot Bonnet, Hélène Labussière-Wallet, Pauline Dumez, Lucie Jauffret, Lyderic Aubert, Aurélie Avondo-Ray, Carole Seurret, Perrine Devic, Sabrine Souci, Syria Laperche, Léa Saint Martin, Emilie Frobert, Alexandre Gaymard, Jennifer Giorgi, Quentin Semanas, Richard Chalvignac, Antoine Oblette, Audrey Lapendry, Bruno Pozzetto, Thomas Perpoint, Mikail Kelleci, Aurélie Sécula, Charlotte Foret-Lucas, Clement Javaux, Florence Morfin, Antonin Bal, Elise Brottet, Catarina Krug, Frederic Jourdain, David Meyronet, Florence Ader, Jean-Luc Guérin, Laurence Josset, Grégory Destras
Institutions: Hospices Civils de Lyon, Hôpital Lyon Sud, Établissement Français du Sang, Hôpital de la Croix-Rousse, Lyon 1 Université, École Normale Supérieure de Lyon, Centre National de la Recherche Scientifique, Inserm, Centre International de Recherche en Infectiologie, Université Jean Monnet, Université Jean Monnet, École Nationale Vétérinaire de Toulouse, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Interactions hôtes-agents pathogènes, Université de Toulouse, Santé Publique France, Centre de Recherche en Cancérologie de Lyon
Language: English
Topic: Viral Infections and Vectors
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7223288683