Work

Ordinal reduction of frontotemporal sulcal asymmetry with increasing auditory verbal hallucinations in schizophrenia spectrum disorders

Year: 2026

Type: article

Study design: Observational Study

Abstract: Asymmetry in paracingulate sulcus (PCS) length and superior temporal sulcus (STS) depth was examined in schizophrenia spectrum patients stratified by auditory verbal hallucination (AVH) frequency. An ordinal reduction in sulcal asymmetry was observed with increasing AVH frequency, reaching statistical significance only for STS depth. The decline in effect size from frequent to less frequent AVH may explain prior inconsistent findings from binary AVH classifications that disregard clinical heterogeneity.

Source: Schizophrenia

DOI: 10.1038/s41537-026-00821-3

Authors: Shun-Chin Jim Wu, Héloïse de Vareilles, Pilar Salgado-Pineda, Lucila Barbosa, Joan Soler-Vidal, Paola Fuentes-Claramonte, Pablo del Olmo-Encabo, Emili Inarejos-Clemente, Begoña Hoyos, Núria Ramiro, Jesús Ruiz, Fernando Boatas, John Suckling, Edith Pomarol-Clotet, Peter J. McKenna, Graham K. Murray

Institutions: University of Cambridge, Fidmag Sisters Hospitallers, Universitat Jaume I, Hospital Sant Joan de Déu Barcelona, Fundació Hospital Sant Joan de Déu de Martorell, Cambridgeshire and Peterborough NHS Foundation Trust

Language: English

Topic: Schizophrenia research and treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,890

Funders: National Institute for Health and Care Research, Department of Health and Social Care, Centro de Investigación Biomédica en Red de Salud Mental, Agència de Gestió d'Ajuts Universitaris i de Recerca, NIHR Cambridge Biomedical Research Centre

Awards: G2493601830, G2537968379, G353605860, G398612900

OpenAlex ID: W7223290025

FWCI:

Cites: 19

Cited by:

Related to: 10