Work

Perioperative Cerebral Metabolism in Patients Under General Anaesthesia With Sevoflurane or Propofol: Evaluation of the Arterial and Jugular Bulb Metabolome

Year: 2026

Type: article

Abstract: Objective: Arterial serum was generally used to uncover shifts in the metabolic profile induced by surgery and anaesthesia. The specific perioperative metabolic alterations in the brain remain largely unknown. We aimed to detect perioperative changes in cerebral metabolism by arteriovenous gradients of circulating metabolites across the brain using liquid chromatography-tandem mass spectrometry (LC-MS) analysis. Methods: The prospective study was conducted at Sichuan Provincial People's Hospital, China. Twenty patients with unilateral pulmonary lesion were recruited. Patients undergoing thoracic surgery were randomised to receive general anaesthesia with sevoflurane or propofol. Blood samples from radial artery and jugular bulb were collected before and after first anaesthetic administration, at the end of 60 min of maintenance of anaesthesia and 60 min after patients regained consciousness. LC-MS-based untargeted metabolomics strategies were used to determine the difference in abundance of circulating metabolites between artery and jugular bulb. Results: A total of 3900 metabolites were detected. Potential critical alterations of metabolites including phosphatidylcholine (PC), phosphatidylethanolamine (PE), choline, isocitrate and lactate and pathways were identified. Brain took up PC and PE in group sevoflurane but secreted these compounds in group propofol. Additionally, propofol was associated with the release of choline and isocitrate from brain. In both groups, lactic acid entered brain intraoperatively. Conclusion: Chinese Clinical Trial Registry: ChiCTR2500111204.

Source: Anesthesiology Research and Practice

DOI: 10.1155/anrp/8559251