Work

Integrative network pharmacology and experimental validation to decipher the anti-angiogenic mechanisms of Xuandan Sanjie decotion in adenomyosis.

Year: 2026

Type: article

Abstract: OBJECTIVE: To investigate the mechanisms by which Xuandan Sanjie decoction (, XSD) inhibits angiogenesis in adenomyosis (AM), using both AM-derived primary endometrial stromal cells (ESCs) and a mouse model. METHODS: )-induced hypoxia-mimicking ESC model and an AM mouse model were established to experimentally validate the anti-angiogenic effects of XSD. RESULTS: experiments, XSD exhibits anti-angiogenic properties through ESR1/G protein-coupled estrogen receptor (GPER)-mediated HIF-1α signaling. CONCLUSION: ESR1/GPER-mediated HIF-1α signaling. These findings elucidate the molecular mechanisms underlying XSD's therapeutic effects for abnormal uterine bleeding associated with adenomyosis, offering new therapeutic strategies for this condition.

Source: PubMed Central

DOI: 10.19852/j.cnki.jtcm.20260514.001

Authors: Gan Lin, Zhou Fangfang, Qiu Yingying, Huang Meihua, L I Zhenli, Gui Tao

Institutions: Nanjing University of Chinese Medicine, China Pharmaceutical University, Xuzhou Medical College

Language: English

Topic: Endometriosis Research and Treatment

Subfield: Reproductive Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Natural Science Foundation of China