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Successful treatment with BrECADD in a patient with Dubin-Johnson syndrome and classic Hodgkin lymphoma: a case report

Year: 2026
Type: article
Study design: Case Report
Abstract: Dubin-Johnson syndrome (DJS) results from ABCC2/MRP2 mutations causing impaired biliary transport. MRP2 also mediates hepatic elimination of chemotherapeutic agents, yet no data exist on anthracycline-based chemotherapy in adult DJS patients. We report a 26-year-old male with advanced-stage classic Hodgkin lymphoma and DJS harboring a novel homozygous ABCC2 variant (c.2291G>A, p.Gly764Asp). After a pembrolizumab prephase, full-dose BrECADD was administered, and samples were taken for therapeutic drug monitoring (TDM), which demonstrated normal etoposide and doxorubicin pharmacokinetics. Complete metabolic remission was achieved without significant toxicity. This case demonstrates that TDM-guided, full-dose anthracycline-based chemotherapy is feasible in DJS.
DOI: 10.1007/s00280-026-04975-w
Authors: Hishan Tharmaseelan, Christian Peter Jaworek, Peter Borchmann, Conrad-Amadeus Voltin, Martin Galler, Gareth J. Veal, Louisa Lepkes, Björn Reusch, Clara Velmans, Christian Netzer, Wenyu Yang, Uwe Fuhr, Shelby Barnett
Language: English
Subfield: Oncology
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $4,390
OpenAlex ID: W7223327873
FWCI:
Cites: 15
Cited by:
Related to: 10