Work

Real‐world evidence of physical comorbidity patterns and all‐cause mortality in patients with mental disorders

Year: 2026

Type: article

Abstract: To the Editor:Mental disorders and physical diseases have a bidirectional relationship, and their co-occurrence is associated with increased mortality and reduced quality of life.[1][2][3] Although dysfunction in different organ systems may have differential effects on mental health outcomes, how physical diseases cluster among individuals with mental disorders and how these patterns relate to mortality remain poorly characterised.Clarifying these patterns may inform risk stratification and integrated care strategies.We therefore examined patterns of physical multimorbidity among individuals with mental disorders and their associations with all-cause mortality in a large real-world population.We conducted an observational study using population-based electronic health record data from 160 healthcare facilities in Yichang, central China, between 1 January 2016 and 31 December 2023.4 The study included 70 897 patients aged ≥ 20 years with a diagnosis of mental disorders, identified using International Classification of Diseases, 10th Revision (ICD-10) codes F30-F39, F40-F48 and F50-F51.Physical conditions were defined using three-digit ICD-10 codes.Diagnoses coded under pregnancy, symptoms and signs, external causes, healthcare encounters and special-purpose codes (ICD-10 chapters O, R, V-Y, Z and U) were excluded.Acute infectious diseases were also excluded to reduce potential bias arising from transient or short-term conditions.Physical diseases with a prevalence greater than 1% were included, and all cancer types were grouped into a single category.Latent class analysis, implemented using the poLCA package in R, was applied to binary indicators of disease presence to

Source: General Psychiatry

DOI: 10.1002/gps3.70070

Authors: Zuolin Lu, Elaine He Xu, Yunyuan Kong, Ruitai Shao, Chen Wang

Institutions: Chinese Academy of Medical Sciences & Peking Union Medical College, First Affiliated Hospital of Nanchang University

Language: English

Topic: Chronic Disease Management Strategies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Peking Union Medical College, Bijzonder Onderzoeksfonds UGent