Work

Research progress on the mechanism of microglia–astrocyte signal crosstalk in central sensitization of vestibular migraine

Year: 2026

Type: article

Abstract: Vestibular migraine (VM) is a vestibular disorder characterized by recurrent episodes of vertigo, frequently accompanied by headache, nausea, and vomiting, which substantially reduce patients’ quality of life. The pathogenesis of VM remains incompletely understood. Current studies mainly focus on ion channel dysfunction, trigeminovascular mechanisms, and genetic susceptibility. Increasing evidence suggests that neuroinflammation and central sensitization play important roles in the onset and maintenance of VM. Microglia and astrocytes are key mediators of central sensitization, and their bidirectional communication represents an important component of neuroimmune interactions in the central nervous system. Based on recent studies, this review systematically summarizes the interactions and crosstalk between microglia and astrocytes in central sensitization, aiming to provide further insight into the pathophysiology of VM and to explore potential preventive and therapeutic strategies.

Source: Frontiers in Neuroscience

DOI: 10.3389/fnins.2026.1844932