Work

Association between mean ocular perfusion pressure and proliferative diabetic retinopathy in a northern Chinese population

Year: 2026

Type: article

Abstract: Background: To evaluate the associations of mean ocular perfusion pressure (MOPP), pulse pressure (PP), and systolic blood pressure (SBP) with proliferative diabetic retinopathy (PDR) among patients with type 2 diabetes in a northern Chinese population. Methods: A retrospective cross-sectional study included 1,323 participants, comprising 1,119 patients from the Beichen Eye Study and 204 patients identified from electronic medical records at the Tianjin Medical University Eye Hospital. The participants were categorized into no diabetic retinopathy (NDR), non-proliferative diabetic retinopathy (NPDR), and PDR groups. SBP, diastolic blood pressure (DBP), and intraocular pressure (IOP) were measured. PP was defined as the difference between SBP and DBP. MOPP was calculated using the formula: MOPP = 2/3 (DBP + 1/3 PP) - IOP. Results: With PDR as the reference category, higher MOPP was associated with PDR relative to both NDR (OR, 0.92; 95% CI, 0.89-0.95) and NPDR (OR, 0.94; 95% CI, 0.91-0.98). SBP and PP showed similar patterns in their respective adjusted models and tertile analyses. Exploratory analyses showed evidence of nonlinear associations for PP (P for likelihood test = 0.046) and IOP (P for likelihood test < 0.001), but not for SBP or MOPP. Conclusions: Higher MOPP was associated with PDR relative to both NDR and NPDR, suggesting that MOPP may provide complementary hemodynamic information in relation to DR severity.

Source: Frontiers in Endocrinology

DOI: 10.3389/fendo.2026.1921927